I am open to suggestions on defence against C4. Any transpositional lines in blacks favor? Any other possibilities? I do not like E4 as a response as I dont play the Sicilian reversed all that well. Ideas? Thanks!

Tons of possibilities.

Some notes on the subject. The English isn't something to fear, though it can have its sting as well as any other opening area.
What do you play against 1. d4? You can very likely play the same system against 1. c4 with some adjustments.

1. c4 e5 is probably the best way to go objectively. People fear the Sicilian sometimes (while I think that isn't quite necessary), it has enough potency to knock over anyone using 1. e4. Why then, if the Sicilian is so good, would anyone want to play into it a move down? An odd answer: at times, the extra move hinders white by having to commit to a certain move.
It's not to everyone's taste however.

When I began my chess life (a few years ago) I opted for 1. ... f5 and a classical Dutch setup (f5+e6+Nf6+Be7+0-0) as I did against 1. d4. I've had good results with that because I knew it well.
Nowadays I play 1. ... Nf6 (followed by e6+b6+Bb7) if I don't transpose into a Nimzo-Indian, a Queen's Indian setup will do me fine.

I could play a Reversed Sicilian when need be. I feel I'll be accomodating my opponents a little too much when I do however.

Thanks Perseus I will give it a try.

Hey. Well, i was the same as you about responding to 1.c4
About 5 yrs ago my old chess coach recommended to me the English Defence. 1.c4 b6 2.d4 e6 to play against 1.c4.
To be honest, at first i found it hard as black accepts in some lines cramped positions, but perfectly ok positions! in fact, black offers the centre to white allowing him 3 pawn centre c4,d4 and e4. Although whites centre looks overpowering black undermines whites centre and can leave his pawns in a mess. Nigel Short has games using this system as black but Tony Miles is the players games you need to study if you take up this opening. It may sound a little boring ie. allowing white to take centre, black suffer space advantage however! blacks bishop on b7(long diagonal) followed by ...f5 and ...Qh4 you can get some pretty wild exciting games (for blitz and serious games) as whites g2 pawn, a8-h1 diagonal and rook h1 can be weak.
I must admit that i have been using this on Fritz/playchess.com and you would not believe the amount of people as white who will take you up on accepting the c4,d4,e4 centre. After some simple pinning (but accurate) and development you can easily find yourself a pawn up after very few moves!
Another advantage of this opening is you dont need to learn theory as such, but rather understand the concepts behind it. Have a look and let me know if it helps