I have neither the time nor inclination to study so I rely heavily on “systems” that can be set up against anything. Torre or Colle, QGD Tartakower and French Rubinstein. I gave up the Caro-Kann…the Advance variation was giving be a lot of trouble. I’m familiar with the patterns and strategy, but they seem too slow (except maybe the QGD Tartakower) to offer much against players rated over, say, 2000. GM Alex Yermolinsky’s advice seems best. He recommends avoiding “weak stuff”: Sicilian GP Attack, Sicilian Rossolimo, offbeat openings, etc. He recommends choosing a couple mainline, solid openings that will serve you well for years to come and playing them. Basically, I guess, play what you see the GM’s playing. If you don’t mind actually studying, that would seem to be the best advice.